NCOG-16. A PILOT STUDY OF COGNITIVE FUNCTIONS APOE AND AMYLOID IMAGING IN GLIOMA PATIENTS

摘要

BACKGROUNDMany patients with brain tumors treated with radiotherapy (RT) and chemotherapy develop cognitive dysfunction, and recent studies suggest that the Apolipoprotein E (APOE) ε-4 allele may influence cognitive outcome in cancer patients. The APOE ε-4 allele is known to promote deposition of beta (β) amyloid in the cortex, and preliminary evidence suggests that RT may be associated with this process. However, it is unknown whether β-amyloid accumulation may contribute to treatment-related neurotoxicity. In this pilot study, we assessed neuropsychological functions and β-amyloid retention using 18F-florbetaben PET in a subset of brain tumor patients who participated in our study of APOE polymorphisms and cognitive functions.