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Loss of heterozygosity 1p/19q and survival in glioma: a meta-analysis

机译：胶质瘤杂合性1p / 19q的丧失和存活：一项荟萃分析

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BackgroundGlioma is rarely curable, and factors that inﬂuence the prognosis of glioma patients are not fully understood. Loss of heterozygosity (LOH) of 1p/19q has long been known to be a typical molecular signature of oligodendroglial neoplasms. However, whether LOH of 1p/19q is associated with survival in gliomas remains controversial. Here our goal was to evaluate the association between LOH of 1p/19q and progression-free survival (PFS) and overall survival (OS) by conducting a meta-analysis among glioma cases.

机译：背景胶质瘤几乎无法治愈，影响胶质瘤患者预后的因素尚不完全清楚。长期以来，已知1p / 19q杂合度（LOH）的丧失是少突神经胶质瘤的典型分子特征。然而，1p / 19q的LOH是否与神经胶质瘤的生存有关仍存在争议。在这里，我们的目标是通过对神经胶质瘤病例进行荟萃分析，评估1p / 19q的LOH与无进展生存期（PFS）和总生存期（OS）之间的关联。

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期刊名称 Neuro-Oncology
作者
Jiaxin Zhao; Wenjie Ma; Hong Zhao;
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作者单位

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年(卷),期 2014(16),1
年度 2014
页码 103–112
总页数 10
原文格式 PDF
正文语种
中图分类神经病学;肿瘤学;
关键词
1p 19q glioma meta-analysis survival;

机译：1p;19q;神经胶质瘤;荟萃分析;生存;

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专利

1. Loss of heterozygosity 1p/19q and survival in glioma: a meta-analysis [J] . Jiaxin Zhao, Wenjie Ma, Hong Zhao Neuro-Oncology . 2014,第1期

机译：胶质瘤杂合性1p / 19q的丧失和存活：一项荟萃分析
2. Loss of FUBP1 expression in gliomas predicts FUBP1 mutation and is associated with oligodendroglial differentiation, IDH1 mutation and 1p/19q loss of heterozygosity [J] . BaumgartenP., HarterP.N., T?njesM., Neuropathology and applied neurobiology . 2014,第2期

机译：胶质瘤中FUBP1表达的丧失预示着FUBP1突变，并与少突胶质细胞分化，IDH1突变和1p / 19q杂合性丧失相关
3. Calcification on CT is a simple and valuable preoperative indicator of 1p/19q loss of heterozygosity in supratentorial brain tumors that are suspected grade II and III gliomas [J] . Saito Taiichi, Muragaki Yoshihiro, Maruyama Takashi, Brain tumor pathology . 2016,第3期

机译：CT钙化是怀疑为II和III级神经胶质瘤的幕上脑肿瘤的1p / 19q杂合性丧失的简单而有价值的术前指标
4. Non-invasive genotype prediction of chromosome 1p/19q co-deletion by development and validation of an MRI-based radiomics signature in lower-grade gliomas [C] . Yuqi Han, Zhen Xie, Yali Zang, SPIE Conference on Computer-Aided Diagnosis . 2019

机译：染色体1P / 19Q型较低级胶质瘤中MRI基辐射瘤的开发和验证染色体1P / 19Q共缺失的非侵袭性基因型预测
5. The Effect of Skewed Elevation in dNTP Pools on Loss of Heterozygosity in Saccharomyces cerevisiae [D] . Badar, Jumana. 2018

机译：dNTP库中偏斜升高对酿酒酵母杂合性丧失的影响
6. P17.01CHROMOSOME ARM 9P LOSS OF HETEROZYGOSITY IS A MARKER OF SHORTER SURVIVAL IN 1P/19Q CO-DELETED ANAPLASTIC OLIGODENDROGLIOMA. A POLA NETWORK STUDY [O] . A. Alentorn, C. Dehais, C. Carpentier, 2014

机译：P17.01染色体9M异质性缺失是1P / 19Q共删除的无胶体少突胶质瘤中更短生存期的标志。 POLA网络研究
7. Differential proteome analysis of human gliomas stratified for loss of heterozygosity on chromosomal arms 1p and 19q [O] . Grzendowski, Michael, Wolter, Marietta, Riemenschneider, Markus J., 2010

机译：人类神经胶质瘤的差异蛋白质组学分析，针对染色体臂1p和19q上的杂合性丧失进行了分层

Loss of heterozygosity 1p/19q and survival in glioma: a meta-analysis

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