C57BL/6J DBA/2J and DBA/2J.Gpnmb+ mice have different visual signal processing in the inner retina

摘要

PurposeTo characterize differences in retinal ganglion cell (RGC) function in mouse strains relevant to disease models. C57BL/6J (B6) and DBA/2J (D2) are the two most common mouse strains; D2 has two mutated genes, tyrosinase-related protein 1 (Tyrp1) and glycoprotein non-metastatic melanoma protein B (Gpnmb), causing iris disease and intraocular pressure (IOP) elevation after 6 months of age that results in RGC degeneration, and is the most widely used model of glaucoma. DBA/2J.Gpnmb⁺ (D2.Gpnmb⁺) is the wild type for the Gpnmb mutation and does not develop IOP elevation and glaucoma.