Cytotoxic Polyketides from the Marine Sponge-Derived Fungus Pestalotiopsis heterocornis XWS03F09

摘要

Four new compounds, including two new polyketides, heterocornols M and N (>1, >2), and a pair of epimers, heterocornols O and P (>3, >4), were isolated from the fermentation broth of the marine sponge-derived fungus Pestalotiopsis heterocornis XWS03F09, together with three known compounds (>5–>7). The new chemical structures were established on the basis of a spectroscopic analysis, optical rotation, experimental and calculated electronic circular dichroism (ECD). All of the compounds (>1–>7) were evaluated for their cytotoxic activities, and heterocornols M-P (>1–>4) exhibited cytotoxicities against four human cancer cell lines with IC50 values of 20.4–94.2 μM.