Novel 5′-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano23-dPyrimidine Nucleosides

摘要

Here we report the synthesis and biological activity of new 5′-norcarbocyclic derivatives of bicyclic pyrrolo- and furano[2,3-d]pyrimidines with different substituents in the heterocyclic ring. Lead compound >3i, containing 6-pentylphenyl substituent, displays inhibitory activity with respect to a number of tumor cells with a moderate selectivity index value. Compound >3i induces cell death by the apoptosis pathway with the dissipation of mitochondrial potential.