Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

摘要

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (>1), a pyrrole alkaloid (>11), and a benzenoid (>17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.