A Greener Efficient Approach to Michael Addition of Barbituric Acid to Nitroalkene in Aqueous Diethylamine Medium

摘要

An efficient method for the synthesis of a variety of pyrimidine derivatives >3a–>t by reaction of barbituric acids >1a,>b as Michael donor with nitroalkenes >2a–>k as Michael acceptor using an aqueous medium and diethylamine is described. This 1,4-addition strategy offers several advantages, such as using an economic and environmentally benign reaction media, high yields, versatility, and shorter reaction times. The synthesized compounds were identified by ¹H-NMR, ¹³C-NMR, CHN, IR, and MS. The structure of compound >3a was further confirmed by single crystal X-ray structure determination.