Phenolic Compounds from the Flowers of Bombax malabaricum and Their Antioxidant and Antiviral Activities

摘要

Three new phenolic compounds >1–>3 and twenty known ones >4–>23 were isolated from the flowers of Bombax malabaricum. Their chemical structures were elucidated by spectroscopic analyses (IR, ESI-MS, HR-ESI-MS, 1D- and 2D-NMR) and chemical reactions. The antioxidant capacities of the isolated compounds were tested using FRAP and DPPH radical-scavenging assays, and compounds >4, >6, >8, >12, as well as the new compound >2, exhibited stronger antioxidant activities than ascorbic acid. Furthermore, all of compounds were tested for their antiviral activities against RSV by the CPE reduction assay and plaque reduction assay. Compounds >4, >10, >12 possess in vitro antiviral activities, and compound >10 exhibits potent anti-RSV effects, comparable to the positive control ribavirin.