Antioxidant and Antitumor Activities of New Synthesized Aromatic C-Nucleoside Derivatives

摘要

The carbohydrazide >1 was used as the precursor for the synthesis of a number of new aromatic C-nucleosides containing 1,3,4-oxadiazole >7, [1,3,4]oxadiazolo[2,3-a]isoindole >10b and pyrazole units >18. On the other hand, the thiosemicarbazone >20 was used as the key intermediate for synthesis of 1,3,4-oxadiazole and 1,2,4-triazole-3-thione derivatives >21 and >23. The antioxidant activities of the prepared compounds were evaluated. The carbohydrazide >1 in particular was found to have potent antioxidant and antitumor activity.