Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines

摘要

Twelve drimanes, including polygodial (>1), isopolygodial (>2), drimenol (>3), confertifolin (>4), and isodrimenin (>5), were obtained from natural sources. Semi-synthetic derivatives >6–>12 were obtained from >1 and >2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5–100 µM of each compound for 72 h. In addition, it was found that polygodial (>1), >8, and >12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.