Synthesis and Anti-TMV Activity of Dialkyl/dibenzyl 2-((6-Substituted-benzodthiazol-2-ylamino)(benzofuran-2-yl)methyl) Malonates

摘要

Starting from benzofuran-2-methanal, 6-substituted benzothiazole-2-amines and malonic esters, sixteen title compounds were designed and synthesized seeking to introduce anti-TMV activity. The structures of the newly synthesized compounds were confirmed by ¹H-NMR, ¹³C-NMR, IR spectra, and MS (HREI) analysis. The bioassays identified some of these new compounds as having moderate to good anti-TMV activity. The compounds >5i and >5m have good antiviral activity against TMV with a curative rate of 52.23% and 54.41%, respectively, at a concentration of 0.5 mg/mL.