A Novel 18-Norclerodane Diterpenoid from the Roots of Tinospora sagittata var. yunnanensis

摘要

A novel 18-nor-clerodane diterpenoid named sagitone (>1) was isolated from the 95% ethanol extract of dry roots of Tinospora sagittata var. yunnanensis together with the five known diterpenoids columbin (>2), palmatoside C (>3), fibleucin (>4), tinophylloloside >(5) and epitinophylloloside (>6). The structure of the new compound >1 was determined based on MS, IR, 1D and 2D NMR spectral data. The compounds >1~6 did not show significant cytotoxic activity against cancer cell lines K562 and HL-60.