Synthesis and Antiviral Bioactivities of α-Aminophosphonates Containing Alkoxyethyl Moieties

摘要

A simple, efficient, and general method has been developed for the synthesis of various α-aminophosphonate derivatives >4a->4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)- or bis(2-ethoxyethyl) phosphite under microwave irradiation without solvents and catalysts. The products were characterized by elemental analysis, IR, ¹H-NMR, ¹³C- and ³¹P-NMR spectra. The X-ray crystallographic data of the representative compound >4l was determined. The new α-aminophosphonate derivatives were found to possess moderate to good antiviral activity.