Synthesis and Antiviral Bioactivities of alpha-Aminophosphonates Containing Alkoxyethyl Moieties

摘要

A simple,efficient,and general method has been developed for the synthesis of Various alpha-aminophosphonate derivatives 4a-4l by treatment of substituted benzaldehydes and aniline with bis(2-methoxyethyl)-or bis(2-ethoxyethyl)phosphite under microwave irradiation without solvents and catalysts.The products were characterized by elemental analysis,IR, ~1 H-NMR, ~13 C-and ~31 P-NMR spectra.The X-ray crystallographic data of the representative compound 4l was determined.The newα-aminophosphonate derivatives were found to possess moderate to good antiviral activity.