One-Pot Quinazolin-4-yl-thiourea Synthesis via N-(2-Cyano- phenyl)benzimidoyl isothiocyanate

摘要

1-substituted-3-(2-phenylquinazolin-4-yl) thioureas (>7) were produced by an intramolecular cycloaddition reaction of 1-substitued-3-[(2-cyanophenyl- imino)phenylmethyl] thioureas (>3). These compounds in turn were prepared by the reaction of N-(2-cyanophenyl)benzimidoyl isothiocyanate (>2) with primary amines. The structures of products >7 were confirmed by FTIR, ¹H-NMR, ¹³C-NMR, mass spectroscopy and X-ray crystallography.