The PBAF chromatin remodeling complex represses transcription and promotes rapid repair at DNA double-strand breaks

摘要

Transcription in the vicinity of DNA double-strand breaks (DSBs) is suppressed via a process involving ataxia telangiectasia mutated protein (ATM) and H2AK119 ubiquitylation. We discuss recent findings that components of the Polybromo and Brahma-related gene 1 (BRG1)-associated factor (PBAF) remodeling complex and the polycomb repressive complex (PRC1/2) are also required. Failure to activate transcriptional suppression impedes a rapid DSB repair process.