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Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients

机译：组织蛋白酶B在肝细胞癌中的过表达预示肝癌患者预后不良

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BackgroundSeveral studies have found that Cathepsin B (CTSB) is up-regulated in many tumor types and facilitates tumor progression. However, the role of CTSB in hepatocellular carcinoma (HCC) progression remains unclear. This study was aimed at investigating the expression and role of CTSB in HCC in a large set of samples and cell lines (MHCC-97H and MHCC-97 L), and evaluating the clinical and prognostic significance of CTSB protein in patients with HCC.

机译：背景多项研究发现，组织蛋白酶B（CTSB）在许多肿瘤类型中均上调，并促进肿瘤进展。但是，CTSB在肝细胞癌（HCC）进展中的作用仍不清楚。这项研究旨在研究CTSB在大量样本和细胞系（MHCC-97H和MHCC-97L）中在肝癌中的表达和作用，并评估CTSB蛋白在肝癌患者中的临床和预后意义。

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期刊名称 Molecular Cancer
作者
Jian Ruan; Haiyan Zheng; Xiaodong Rong; Xiaomin Rong; Junyi Zhang; Weijia Fang; Peng Zhao; Rongcheng Luo;
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作者单位

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年(卷),期 2016(15),-1
年度 2016
页码 17
总页数 13
原文格式 PDF
正文语种
中图分类分子生物学;肿瘤学;
关键词
Hepatocellular carcinoma Cathepsin B Prognostic marker;

机译：肝细胞癌;组织蛋白酶B;预后标志物;

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专利

1. Higher PKD3 expression in hepatocellular carcinoma (HCC) tissues predicts poorer prognosis for HCC patients [J] . Haiyun Yang, Ming Xu, Xiufang Chi, Clinics and research in hepatology and gastroenterology . 2017,第5期

机译：肝细胞癌（HCC）组织中较高的PKD3表达预测HCC患者的预后差
2. Overexpression of Tiam1 in hepatocellular carcinomas predicts poor prognosis of HCC patients. [J] . Ding Y, Chen B, Wang S, International Journal of Cancer =: Journal International du Cancer . 2009,第3期

机译：Tiam1在肝细胞癌中的过表达预示了HCC患者的预后不良。
3. Tenascin-C expression is associated with poor prognosis in hepatocellular carcinoma (HCC) patients and the inflammatory cytokine TNF-α-induced TNC expression promotes migration in HCC cells [J] . Yunhong Nong, Dongbo Wu, Yong Lin, American Journal of Cancer Research . 2015,第2期

机译：Tenascin-C表达与肝细胞癌（HCC）患者的预后不良有关，炎性细胞因子TNF-α诱导的TNC表达促进肝癌细胞迁移
4. A Ten-Long Non-coding RNA Model Improves Prognosis Prediction of Hepatocellular Carcinoma Patients [C] . Xiaonan Fang, Naiwen Liu, Yanling Du, International Conference on Information Technology in Medicine and Education . 2018

机译：10个长的非编码RNA模型可提高肝细胞癌患者的预后预测
5. Baseline Toronto HCC Risk Index (THRI) and Albumin Predict Low Risk of Hepatocellular Carcinoma (HCC) after Sustained Virological Response (SVR) in HCV Infection [D] . Lau, Jason. 2019

机译：基线多伦多HCC风险指数（THRI）和白蛋白预测HCV感染持续病毒响应（SVR）后肝细胞癌（HCC）的低风险
6. Tenascin-C expression is associated with poor prognosis in hepatocellular carcinoma (HCC) patients and the inflammatory cytokine TNF-α-induced TNC expression promotes migration in HCC cells [O] . Yunhong Nong, Dongbo Wu, Yong Lin, 2015

机译：Tenascin-C表达与肝细胞癌（HCC）患者的不良预后相关炎性细胞因子TNF-α诱导的TNC表达促进肝癌细胞迁移
7. Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients [O] . Jian Ruan, Haiyan Zheng, Xiaodong Rong, 2016

机译：组织蛋白酶B在肝细胞癌中的过表达预示肝癌患者预后不良

Over-expression of cathepsin B in hepatocellular carcinomas predicts poor prognosis of HCC patients

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