Toxicity Profiles In Vivo in Mice and Antitumour Activity inTumour-Bearing Mice of Di- and Triorganotin Compounds

摘要

The in vivo toxicity profiles in mice and the antitumour activity in tumour bearing mice were screened for four di-n-butyltin and five triorganotin carboxylates, di-n-butyltin diterebate (>5), bis(phenylacetate) (>6), bis(deoxycholate) (>7), bis(lithocholate) (>8), tri-n-butyltin terebate (>9), cinnamate (>10), and triphenyltin terebate (>11).At their maximum tolerated dosis (MTD), no antitumour effect (T/C ~1) was observed for the compounds >5, >7, >9, >10 and >11. The compounds >6 (T/C = 0.51) and >8 (T/C = 0.42) showed clear antitumour activity after single dose administration and might therefore be of interest for further antitumour activity studies.