Leonurine Exerts Anti-Catabolic and Anti-Apoptotic Effects via Nuclear Factor kappa B (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways in Chondrocytes

机译：益母草碱通过软骨细胞中的核因子κB（NF-κB）和丝裂原激活的蛋白激酶（MAPK）信号传导途径发挥抗代谢和抗凋亡作用

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BackgroundLeonurine confers neuroprotection, inhibits myocardial apoptosis, ameliorates endothelial dysfunction, and shows anti-inflammatory effects, and may be beneficial for clinical applications. However, the effects of leonurine on chondrocytes remain unknown. Here, we investigated the protective role of leonurine in rat chondrocytes.

机译：背景leonurine赋予神经保护作用，抑制心肌细胞凋亡，改善内皮功能障碍，并显示抗炎作用，可能对临床应用有益。然而，leonurine对软骨细胞的作用仍然未知。在这里，我们调查了Leonurine在大鼠软骨细胞中的保护作用。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Peng-Fei Hu; Fang-Fang Sun; Jing Qian;
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年(卷),期 2019(25),-1
年度 2019
页码 6271–6280
总页数 10
原文格式 PDF
正文语种
中图分类
关键词
Matrix Metalloproteinases Mitogen-Activated Protein Kinase Phosphatases NF-kappa B Osteoarthritis;

机译：基质金属蛋白酶;丝裂原激活的蛋白激酶磷酸酶;NF-κB;骨关节炎;

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2. Anti-inflammatory effect of flavonoids isolated from Korea Citrus aurantium L on lipopolysaccharide-induced mouse macrophage RAW 264.7 cells by blocking of nuclear factor-kappa B (NF-kB) and mitogen-activated protein kinase (MAPK) signalling pathways [J] . Sang Rim Kang, Kwang Il Park, Hyeon Soo Park, Food Chemistry . 2011,第4期

机译：朝鲜柑桔中的黄酮类化合物通过阻断核因子-κB（NF-kB）和有丝分裂原激活的蛋白激酶（MAPK）信号通路对脂多糖诱导的小鼠巨噬细胞RAW 264.7细胞的抗炎作用
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机译：核因子-κB，p38和应激激活的蛋白激酶促分裂原激活的蛋白激酶信号传导途径调节人胎盘外植体中促炎性细胞因子和细胞凋亡，以响应氧化应激：抗氧化剂的作用
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Leonurine Exerts Anti-Catabolic and Anti-Apoptotic Effects via Nuclear Factor kappa B (NF-κB) and Mitogen-Activated Protein Kinase (MAPK) Signaling Pathways in Chondrocytes

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