microRNA-378a Regulates the Reactive Oxygen Species (ROS)/Phosphatidylinositol 3-Kinases (PI3K)/AKT Signaling Pathway in Human Lens Epithelial Cells and Cataract

机译：microRNA-378a调节人晶状体上皮细胞和白内障中的活性氧（ROS）/磷脂酰肌醇3-激酶（PI3K）/ AKT信号通路

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BackgroundCataract is associated with increased apoptosis of the epithelial cells of the ocular lens. Previous studies have shown that microRNA-378a (miR-378a) has a role in the development of cataract, but the molecular mechanisms remain unclear. This study aimed to investigate the effects of miR-378a in human lens epithelial cells (HLECs) in vitro and normal lens tissues and cataract tissues.

机译：背景白内障与人工晶状体上皮细胞凋亡增加有关。先前的研究表明，microRNA-378a（miR-378a）在白内障的发生中起作用，但分子机制仍不清楚。这项研究旨在调查miR-378a在体外人晶状体上皮细胞（HLEC）和正常晶状体组织以及白内障组织中的作用。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Yan Liu; Huanhuan Li; Yao Liu;
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作者单位

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年(卷),期 2019(25),-1
年度 2019
页码 4314–4321
总页数 8
原文格式 PDF
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关键词
Apoptosis Cataract MicroRNAs Phosphatidylinositol 3-Kinases;

机译：凋亡;白内障;MicroRNA;磷脂酰肌醇3-激酶;

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专利

1. Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)-mediated Lamellipodia Formation, Reactive Oxygen Species (ROS) Generation, and Motility of Lung Endothelial Cells [J] . Peter V. Usatyuk, Panfeng Fu, Vijay Mohan, The Journal of biological chemistry . 2014,第19期

机译：肝细胞生长因子（HGF）介导的肝细胞生长因子（HGF）介导的层状面积，活性氧物质（ROS）产生，肺内皮细胞的运动，C-Met /磷脂酰肌醇3-激酶（PI3K）/ Akt信号传导的作用
2. High Glucose Promotes Tumor Invasion and Increases Metastasis-Associated Protein Expression in Human Lung Epithelial Cells by Upregulating Heme Oxygenase-1 via Reactive Oxygen Species or the TGF-?21/PI3K/Akt Signaling Pathway [J] . Xiaowen Kang, Fanwu Kong, Xiaomei Wu, Cellular Physiology and Biochemistry . 2015,第3期

机译：高糖通过经由活性氧或TGF-β21/ PI3K / Akt信号通路上调血红素加氧酶-1来促进肿瘤侵袭并增加人肺上皮细胞转移相关蛋白的表达。
3. Keratinocyte growth factor (KGF) regulates estrogen receptor-alpha (ER-alpha) expression and cell apoptosis via phosphatidylinositol 3-kinase (PI3K)/Akt pathway in human breast cancer cells. [J] . Chang HL, Sugimoto Y, Liu S, Anticancer Research: International Journal of Cancer Research and Treatment . 2009,第8期

机译：角质形成细胞生长因子（KGF）通过磷脂酰肌醇3-激酶（PI3K）/ Akt通路调节人乳腺癌细胞中的雌激素受体α（ER-alpha）表达和细胞凋亡。
4. Ugonin K induces Cell Cycle Arrest and Apoptosis through Reactive oxygen species/Apoptosis Signal Pathway in Human Skin Cancer Cells [C] . Leong-Perng Chan, Tzung-Han Chou, Guey-Horng Wang, International Conference on Manufacturing Science and Engineering . 2013

机译：Ugonin K通过在人体皮肤癌细胞中的活性氧物质/凋亡信号途径诱导细胞周期停滞和细胞凋亡
5. Crosstalk between the TGF-beta/Smad and PI3K/Akt pathways in the human epithelial MCF10A cell lineage and implications of signaling inhibitors. [D] . Zheng, Jie. 2009

机译：人上皮MCF10A细胞谱系中TGF-beta / Smad和PI3K / Akt通路之间的串扰和信号抑制剂的含义。
6. Role of c-Met/Phosphatidylinositol 3-Kinase (PI3k)/Akt Signaling in Hepatocyte Growth Factor (HGF)-mediated Lamellipodia Formation Reactive Oxygen Species (ROS) Generation and Motility of Lung Endothelial Cells [O] . Peter V. Usatyuk, Panfeng Fu, Vijay Mohan, 2014

机译：c-Met /磷脂酰肌醇3-激酶（PI3k）/ Akt信号在肝细胞生长因子（HGF）介导的片状脂蛋白形成活性氧（ROS）生成和肺内皮细胞运动中的作用
7. High Glucose Promotes Tumor Invasion and Increases Metastasis-Associated Protein Expression in Human Lung Epithelial Cells by Upregulating Heme Oxygenase-1 via Reactive Oxygen Species or the TGF-β1/PI3K/Akt Signaling Pathway [O] . Xiaowen Kang, Fanwu Kong, Xiaomei Wu, 2015

机译：高葡萄糖通过活性氧物种或TGF-β1/ pI3K / akt信号通路上调血红素加氧酶-1，促进肿瘤侵袭并增加人肺上皮细胞中转移相关蛋白的表达

microRNA-378a Regulates the Reactive Oxygen Species (ROS)/Phosphatidylinositol 3-Kinases (PI3K)/AKT Signaling Pathway in Human Lens Epithelial Cells and Cataract

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