Antiproliferative Effects of Matricine in Gemcitabine-Resistant Human Pancreatic Carcinoma Cells Are Mediated via Mitochondrial-Mediated Apoptosis Inhibition of Cell Migration Invasion Suppression and Mammalian Target of Rapamycin (mTOR)-TOR/PI3K/AKT Signalling Pathway

摘要

BackgroundPancreatic cancer is a major cause of mortality worldwide. Inefficient drugs, their adverse effects, and the development of drug resistance make it difficult to curb the growing incidence of pancreatic cancer. Against this backdrop, the development new drug regimens with no or negligible adverse effects is imperative. We assessed the anticancer effects of a plant-derived sesquiterpene – matricine – against capan-2 pancreatic cancer cells.