Classical Hodgkin Lymphoma with Positive Epstein-Barr Virus Status is Associated with More FOXP3 Regulatory T Cells

机译：爱泼斯坦-巴尔病毒阳性的经典霍奇金淋巴瘤与更多的FOXP3调节性T细胞相关

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BackgroundClassical Hodgkin lymphoma (cHL) is characterized by sparse malignant Hodgkin and Reed-Sternberg cells dispersed in an inflammatory microenvironment. Immune evasion of malignant cells is partially due to the existence of a subpopulation of immunosuppressive regulatory T cells (Treg). The aim of this study was to analyze T cell composition in cHL with special emphasis on Treg in regard to Epstein-Barr virus (EBV) status, subtype, and patient age.

机译：背景经典的霍奇金淋巴瘤（cHL）的特征是稀疏的恶性霍奇金和Reed-Sternberg细胞分散在炎性微环境中。恶性细胞的免疫逃避部分归因于免疫抑制性调节性T细胞（Treg）的亚群的存在。这项研究的目的是分析cHL中的T细胞组成，特别是在爱泼斯坦-巴尔病毒（EBV）状态，亚型和患者年龄方面特别关注Treg。

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期刊名称 Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
作者
Antonia Pavlovic; Merica Glavina Durdov; Vesna Capkun; Jasminka Jakelic Pitesa; Maja Bozic Sakic;
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作者单位

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年(卷),期 2016(22),-1
年度 2016
页码 2340–2346
总页数 7
原文格式 PDF
正文语种
中图分类
关键词
Herpesvirus 4 Human; Hodgkin Disease; T-Lymphocytes Regulatory;

机译：疱疹病毒4;人类;霍奇金病;T淋巴细胞;调节性;

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专利

1. Classical Hodgkin Lymphoma with Positive Epstein-Barr Virus Status is Associated with More FOXP3 Regulatory T Cells [J] . Antonia Pavlovic, Merica Glavina Durdov, Vesna Capkun, Medical science monitor : . 2016,第5期

机译：EB病毒状态阳性的经典霍奇金淋巴瘤与更多的FOXP3调节性T细胞相关
2. Increased expression of CD4(+)CD25 (+)FOXP3 (+) regulatory T cells correlates with Epstein-Barr virus and has no impact on survival in patients with classical Hodgkin lymphoma in Brazil. [J] . Mariane C G Assis, Antonio H F M Campos, Jose S R Oliveira, Medical oncology . 2012,第5期

机译：CD4（+）CD25（+）FOXP3（+）调节性T细胞的表达增加与爱泼斯坦巴尔病毒相关，并且对巴西经典霍奇金淋巴瘤患者的生存没有影响。
3. Synchronous Epstein-Barr virus-positive diffuse large B-cell lymphoma of the elderly and Epstein-Barr virus-positive classical Hodgkin lymphoma. [J] . Hwang YY, Leung AY, Lau WH, Histopathology: Official Journal of the British Division of the International Academy of Pathology . 2011,第2期

机译：同步性爱泼斯坦巴尔病毒阳性的老年人弥漫性大B细胞淋巴瘤和爱泼斯坦巴尔病毒阳性的经典霍奇金淋巴瘤。
4. Expression of CD4+CD25+ T regulatory cells and Foxp3 in peripheral blood of patients with Rheumatoid Arthritis Patient [C] . Kexin Sun, Yan Li, Suhong Guo, International Conference on Applied Science, Engineering and Technology . 2013

机译：类风湿性关节炎患者外周血CD4 + CD25 + T调节细胞和FOXP3的表达
5. The role of soluble CD23 and Epstein-Barr virus in the development of AIDS-related non-Hodgkin's lymphoma [D] . Schroeder, Jennifer Reimers. 1999

机译：可溶性CD23和爱泼斯坦-巴尔病毒在与艾滋病相关的非霍奇金淋巴瘤发展中的作用
6. Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin’s Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells [O] . Karl R.N. Baumforth, Anna Birgersdotter, Gary M. Reynolds, 2008

机译：爱泼斯坦-巴尔病毒编码的爱泼斯坦-巴尔病毒核抗原1在霍奇金淋巴瘤细胞中的表达介导CCL20的上调和调节性T细胞的迁移。
7. Expression of the Epstein-Barr Virus-Encoded Epstein-Barr Virus Nuclear Antigen 1 in Hodgkin’s Lymphoma Cells Mediates Up-Regulation of CCL20 and the Migration of Regulatory T Cells [O] . Baumforth, Karl R.N., Birgersdotter, Anna, Reynolds, Gary M., 2008

机译：爱泼斯坦-巴尔病毒编码的爱泼斯坦-巴尔病毒核抗原1在霍奇金淋巴瘤细胞中的表达介导CCL20的上调和调节性T细胞的迁移。

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Classical Hodgkin Lymphoma with Positive Epstein-Barr Virus Status is Associated with More FOXP3 Regulatory T Cells

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