AB085. Improvement of erectile function through combination of anti-fibrotic effect by LIM-kinase 2 inhibitor with suppression of apoptosis and potentiation of endothelial function by type 5 phosphodiesterase inhibitor in a rat model of cavernous nerve injury

摘要

BackgroundThe cavernosal apoptosis and fibrosis are considered to be important pathophysiologies of post-radical prostatectomy (RP) erectile dysfunction (ED). Recently, we demonstrated that inhibition of LIMK2 alleviate ED through suppression of cavernosal fibrosis in a rat model of cavernous nerve (CN) injury. Also, some previous studies showed that administration of PDE5 inhibitors improved both cavernosal apoptosis and endothelial dysfunction in a rat model of CN injury, leading to improvement of ED. Thus, the aim of this study was to determine whether combined administration of LIMK2 inhibitors and PDE5 inhibitors could restore erectile function by combination of anti-fibrotic effect with suppression of apoptosis or potentiation of endothelial function in a rat model of CN injury.