AB072. A feed forward loop between lncARSR and YAP activity promotes expansion of renal tumor-initiating cells

摘要

BackgroundRenal cell carcinoma (RCC) is the most common kidney cancer in adults prognosis. Increasing appreciation of cell heterogeneity and a challenging disease with poor within clear cell renal cell carcinoma (ccRCC) has focused attention on a distinct subpopulation of cells called tumour initiating cells (T-ICs) or cancer stem cells (CSCs) in ccRCC. T-ICs exhibit extended self-renewal potential and tumour initiating ability. Tumours that harbour an abundant T-IC population or have high expression of stemness-related genes may signal a poor clinical outcome in RCC patients. Therefore, identification of the underlying mechanisms governing renal T-ICs propagation may lead to the discovery of promising therapeutic strategies for RCC patients.