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Visual Input Regulates Circuit Configuration in Courtship Conditioning of Drosophila melanogaster

机译:视觉输入调节果蝇求爱条件中的电路配置

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摘要

Courtship and courtship conditioning are behaviors that are regulated by multiple sensory inputs, including chemosensation and vision. Globally inhibiting CaMKII activity in Drosophila disrupts courtship plasticity while leaving visual and chemosensory perception intact. Light has been shown to modulate CaMKII-dependent memory formation in this paradigm and the circuitry for the nonvisual version of this behavior has been investigated. In this paradigm, volatile and tactile pheromones provide the primary driving force for courtship, and memory formation is dependent upon intact mushroom bodies and parts of the central complex. In the present study, we use the GAL4/UAS binary expression system to define areas of the brain that require CaMKII for modulation of courtship conditioning in the presence of visual, as well as chemosensory, information. Visual input suppressed the ability of mushroom body- and central complex-specific CaMKII inhibition to disrupt memory formation, indicating that the cellular circuitry underlying this behavior can be remodeled by changing the driving sensory modality. These findings suggest that the potential for plasticity in courtship behavior is distributed among multiple biochemically and anatomically distinct cellular circuits.
机译:求爱和求爱条件是受多种感觉输入(包括化学感觉和视觉)调节的行为。在果蝇中全局抑制CaMKII活性会破坏求爱的可塑性,同时保持视觉和化学感官知觉不变。在这种范例中,光已经显示出可以调节CaMKII依赖性记忆的形成,并且已经研究了这种行为的非视觉形式的电路。在这种范式中,挥发性和触觉信息素是求偶的主要驱动力,记忆的形成取决于完整的蘑菇体和中央复合体的某些部分。在本研究中,我们使用GAL4 / UAS二元表达系统来定义需要CaMKII调节视觉和化学感官信息存在时求爱条件的大脑区域。视觉输入抑制了蘑菇体和中枢复合物特异的CaMKII抑制破坏记忆形成的能力,表明通过改变驾驶感觉方式可以重塑此行为的细胞回路。这些发现表明,在求爱行为中可塑性的潜力分布在多个生化和解剖学上不同的细胞回路之间。

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