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Association between E469K polymorphism in the ICAM1 gene and the risk of diabetic nephropathy: a meta-analysis

机译:ICAM1基因中E469K多态性与糖尿病肾病风险之间的关联:一项荟萃分析

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摘要

BackgroundInflammation may be a key pathophysiological mechanism in diabetic nephropathy (DN). Intercellular adhesion molecule 1 (ICAM1) is an acute phase marker of inflammation. ICAM1 rs5498 has been reported to be associated with the risk of DN. However, the previous findings were conflicting due to the limited sample sizes, different methodologies and ethnicities. Therefore, this study aimed to investigate the genetic association between ICAM1 rs5498 and the risk of DN.
机译:背景炎症可能是糖尿病肾病(DN)的关键病理生理机制。细胞间粘附分子1(ICAM1)是炎症的急性期标志物。据报道,ICAM1 rs5498与DN的风险有关。但是,由于样本量有限,方法和种族不同,先前的发现存在冲突。因此,本研究旨在调查ICAM1 rs5498与DN风险之间的遗传关联。

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