α-linolenic acid and docosahexaenoic acid alone and combined with trastuzumab reduce HER2-overexpressing breast cancer cell growth but differentially regulate HER2 signaling pathways

摘要

BackgroundDiets rich in the n-3 fatty acid alpha-linolenic acid (ALA) have been shown to reduce breast tumor growth, enhance the effectiveness of the HER2-targeted drug trastuzumab (TRAS) and reduce HER2 signaling in mouse models. It is unclear whether this is due to direct effects of ALA or due to its long-chain n-3 fatty acids metabolites including docosahexaenoic acid (DHA).