The imbalance between Treg and Th17 cells caused by FTY720 treatment in skin allograft rejection

摘要

OBJECTIVES:FTY720 modulates CD4⁺T cells by the augmentation of regulatory T cell activity, secretion of suppressive cytokines and suppression of IL-17 secretion by Th17 cells. To further understand the process of graft rejection/acceptance, we evaluated skin allograft survival and associated events after FTY720 treatment.