Vitiligo is an acquired skin disease that significantly impacts the quality of life of patients. Medical treatment of vitiligo includes the use of melanocyte transplant, but the results are variable. We have treated 4 patients with either focal or generalized stable vitiligo using a graft of autologous melanocytes' culture on a denuded amniotic membrane (AM). A culture biopsy was obtained in every patient and grown in melanocytes' media for 10–14 days after which cells were transferred to a denuded AM and transplanted into the achromic lesions. Patients were followed for up to 6 months using clinical assessment of achromic lesions. Treated areas ranged between 4 cm2 and 210.6 cm2. Response to treatment was excellent in all patients with 90–95% repigmentation success rate. Our results demonstrate that transplantation of autologous melanocytes cultured on AM is a new, simple, and effective treatment for stable vitiligo.
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机译:白癜风是一种获得性皮肤疾病,会严重影响患者的生活质量。白癜风的医学治疗包括使用黑素细胞移植,但结果是可变的。我们在裸露的羊膜(AM)上植入了自体黑素细胞培养物,治疗了4例局灶性或全身性稳定的白癜风患者。每位患者都进行了活检,并在黑素细胞的培养基中生长了10-14天,然后将细胞转移至裸露的AM并移植到无色病变中。使用无色病变的临床评估对患者进行长达6个月的随访。处理面积在4 cm 2 sup>和210.6 cm 2 sup>之间。在所有患者中,治疗成功率均在90%至95%之间,均极佳。我们的结果表明,在AM上培养的自体黑素细胞的移植是稳定白癜风的一种新的,简单而有效的治疗方法。
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