Malaria case clinical profiles and Plasmodiumfalciparum parasite genetic diversity: a cross sectional survey at two sites of different malaria transmission intensities in Rwanda

摘要

BackgroundMalaria remains a public health challenge in sub-Saharan Africa with Plasmodiumfalciparum being the principal cause of malaria disease morbidity and mortality. Plasmodium falciparum virulence is attributed, in part, to its population-level genetic diversity—a characteristic that has yet to be studied in Rwanda. Characterizing P. falciparum molecular epidemiology in an area is needed for a better understand of malaria transmission and to inform choice of malaria control strategies.