Effect of single tablet of fixed-dose amlodipine and atorvastatin on blood pressure/lipid control oxidative stress and medication adherence in type 2 diabetic patients

摘要

BackgroundOxidized low-density lipoprotein (LDL) plays central roles in the formation and progression of atherosclerotic lesions. Malondialdehyde (MDA)-modified LDL (MDA-LDL) is speculated to be generated as a result of oxidative stress in the human body. Because both amlodipine and atorvastatin have been reported to reduce oxidative stress, it is expected that both drugs would have a favorable influence to reduce oxidative stress.