DPP-4 inhibition improves early mortality β cell function and adipose tissue inflammation in db/db mice fed a diet containing sucrose and linoleic acid

摘要

BackgroundDiabetes therapy that not only lowers glucose levels but also lengthens life spans is required. We previously demonstrated that DPP-4 inhibition ameliorated β cell apoptosis and adipose tissue inflammation in β cell-specific glucokinase haploinsufficient mice fed a diet containing a combination of sucrose and linoleic acid (SL).