Immunohistochemistry with apoptotic-antiapoptotic proteins (p53 p21 bax bcl-2) c-kit telomerase and metallothionein as a diagnostic aid in benign borderline and malignant serous and mucinous ovarian tumors

摘要

BackgroundIn many tumors including ovarian cancer, cell proliferation and apoptosis are important in pathogenesis and there are many alterations in most of the genes related to the cell cycle. This study was designed to evaluate immunohistochemistry with apoptotic-antiapoptotic proteins (p53, p21, bax, and bcl-2), c-kit, telomerase, and metallothionein as a diagnostic aid in typing of benign, borderline, and malignant serous and mucinous ovarian tumors.