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Arminin 1a-C a novel antimicrobial peptide from ancient metazoan Hydra shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells

机译：Arminin 1a-C是一种来自古代后生动物Hydra的新型抗菌肽对药物敏感性和耐药性白血病细胞显示出有效的抗白血病活性

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PurposeDue to the emergence of multidrug resistance (MDR), traditional antileukemia drugs no longer meet the treatment needs. Therefore, new antileukemia drugs with different action mechanisms are urgently needed to cope with this situation.

机译：目的由于多药耐药性（MDR）的出现，传统的抗白血病药已不能满足治疗需求。因此，迫切需要新的具有不同作用机制的抗白血病药物来应对这种情况。

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期刊名称 Drug Design Development and Therapy
作者
Xiaolei Liang; Ruirui Wang; Wenshan Dou; Li Zhao; Lanxia Zhou; Junfang Zhu; Kairong Wang; Jiexi Yan;
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作者单位

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年(卷),期 2018(12),-1
年度 2018
页码 3691–3703
总页数 13
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
antimicrobial peptide Arminin 1a-C antileukemia multidrug resistance;

机译：抗菌肽;Arminin 1a-C;抗白血病;多药耐药;

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专利

1. Arminin 1a-C, a novel antimicrobial peptide from ancient metazoan Hydra, shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells [J] . Xiaolei Liang, Ruirui Wang, Wenshan Dou, Drug Design, Development and Therapy . 2018,第4期

机译：Arminin 1a-C是一种来自古代后生动物Hydra的新型抗菌肽，对药物敏感性和耐药性白血病细胞显示有效的抗白血病活性
2. Activity of the novel peptide arminin against multiresistant human pathogens shows the considerable potential of phylogenetically ancient organisms as drug sources. [J] . Augustin R, Anton Erxleben F, Jungnickel S, Antimicrobial agents and chemotherapy. . 2009,第12期

机译：新型肽arminin对抗多药耐药人类病原体的活性显示出系统发育的古老生物作为药物来源的巨大潜力。
3. Redox modulation of adjacent thiols in vla-4 by as101 converts myeloid leukemia cells from a drug-resistant to drug-sensitive state [J] . Layani-BazarA., SkornickI., BerrebiA., Cancer research: The official organ of the American Association for Cancer Research, Inc . 2014,第11期

机译：AS101对VLA-4中相邻硫醇的氧化还原调节将髓样白血病细胞从耐药状态转变为药物敏感状态
4. Antimicrobial Activity and Protection from Triton X-100-Induced Mammalian Cell Membrane Lysis by Artificial Amphiphilic Peptides [C] . M. Tanihara, Y. Yamasaki, Y. Shibasaki European Conference of the International Federation for Medical and Biological Engineering . 2013

机译：用人工两亲肽的Triton X-100诱导的哺乳动物细胞膜裂解的抗菌活性和保护
5. Activity of the Novel Peptide Arminin against Multiresistant Human Pathogens Shows the Considerable Potential of Phylogenetically Ancient Organisms as Drug Sources [O] . René Augustin, Friederike Anton-Erxleben, Stephanie Jungnickel, 2009

机译：新型肽Arminin对抗多重耐药人类病原体的活性显示出系统发生古代生物作为药物来源的巨大潜力
6. Activity of the Novel Peptide Arminin against Multiresistant Human Pathogens Shows the Considerable Potential of Phylogenetically Ancient Organisms as Drug Sources▿ [O] . Augustin, René, Anton-Erxleben, Friederike, Jungnickel, Stephanie, 2009

机译：新型肽Arminin对抗多重耐药人类病原体的活性显示出系统发生古代生物作为药物来源的巨大潜力▿
7. Antimicrobial Peptides Containing Unnatural Amino Acid Exhibit Potent Bactericidal Activity against ESKAPE Pathogens. [R] . Hicks, R. P., Abercrombie, J. J., Wong, R. K., 2013

机译：含有非天然氨基酸的抗菌肽对EsKapE病原体具有强大的杀菌活性。

Arminin 1a-C a novel antimicrobial peptide from ancient metazoan Hydra shows potent antileukemia activity against drug-sensitive and drug-resistant leukemia cells

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