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PEPTIDE HAVING EIGHT AMINO ACID SEQUENCES DERIVED FROM CAGE AND RETAINING ANTICANCER ACTIVITY AND ACTIVITY TO PROMOTE ANTICANCER DRUG SENSITIVITY OF ANTICANCER DRUG-RESISTANT CANCER CELLS
PEPTIDE HAVING EIGHT AMINO ACID SEQUENCES DERIVED FROM CAGE AND RETAINING ANTICANCER ACTIVITY AND ACTIVITY TO PROMOTE ANTICANCER DRUG SENSITIVITY OF ANTICANCER DRUG-RESISTANT CANCER CELLS
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机译:具有从笼子衍生的八氨基酸序列并保持抗癌药活性和促进抗癌药耐药细胞的抗癌药敏感性的活性
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摘要
The present invention relates to a peptide having eight amino acid sequences derived from CAGE and retaining anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells and, specifically, to a peptide, which has an amino acid sequence of SEQ ID NO: 1 (AQTGTGKT) and thus binds to the CAGE protein, thereby inhibiting an inter-linkage between CAGE and GSK3β, thus exhibiting anticancer activity and activity to promote anticancer drug sensitivity of anticancer drug resistant cancer cells, and to a pharmaceutical composition, containing the peptide, for anticancer use or anticancer drug aiding.
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机译:本发明涉及一种肽,其具有源自CAGE的八个氨基酸序列并保持抗癌活性和增强抗癌药抗性癌细胞的抗癌药敏感性的活性,特别是涉及一种具有SEQ ID NO:7的氨基酸序列的肽。 :1(AQTGTGKT)并因此与CAGE蛋白结合,从而抑制CAGE与GSK3β之间的相互联系,从而表现出抗癌活性和增强抗癌药耐药性癌细胞的抗癌药敏感性的活性,并且涉及包含肽,用于抗癌或辅助抗癌药物。
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