Electroporation-enhanced transdermal diclofenac sodium delivery into the knee joint in a rat model of acute arthritis

摘要

PurposeSince electroporation (EP) can increase the permeability of biological membranes, we hypothesized that it offers an opportunity to enhance the transdermal delivery of drugs for intra-articular indications. Our aim was to compare the anti-inflammatory and analgesic efficacy of EP-combined topical administration of diclofenac sodium hydrogel (50 mg mL⁻¹ in 230 µL volume) with that of an equivalent dose of oral (75 mg kg⁻¹) and simple topical administration.