Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

机译：口服LDD175对坦索罗辛和非那雄胺在前列腺增生大鼠模型中的累加作用

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摘要

ObjectiveWe investigated the benefits of the BKCa agonist 4-chloro-7-trifluoromethyl-10H-benzo[4,5]furo[3,2-b]indole-1-carboxylic acid (LDD175) combined with tamsulosin and finasteride, in a benign prostatic hyperplasia (BPH) rat model.

机译：目的我们研究了BKCa激动剂4-氯-7-三氟甲基-10H-苯并[4,5]呋喃[3,2-b]吲哚-1-甲酸（LDD175）与坦洛新和非那雄胺联合使用的良性益处前列腺增生（BPH）大鼠模型。

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期刊名称 Drug Design Development and Therapy
作者
Bo Ram Choi; Hye Kyung Kim; Kiran Kumar Soni; Keshab Kumar Karna; Sung Won Lee; Insuk So; Jong Kwan Park;
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作者单位

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年(卷),期 2018(12),-1
年度 2018
页码 1855–1863
总页数 9
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
α1-adrenoceptors α1-adrenergic receptor antagonists benzofuroindole intraurethral pressure 5α-reductase inhibitors;

机译：α1-肾上腺素受体;α1-肾上腺素受体拮抗剂;苯并呋喃吲哚;尿道内压;5α-还原酶抑制剂;

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专利

1. Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model [J] . Bo Ram Choi, Hye Kyung Kim, Kiran Kumar Soni, Drug Design, Development and Therapy . 2018,第InaProgress期

机译：口服LDD175对坦索罗辛和非那雄胺在前列腺增生大鼠模型中的累加作用
2. An open-label, prospective interventional study of the tolerability and efficacy of 0.4 mg oral tamsulosin oral controlled absorption system in men with lower urinary tract symptoms associated with benign prostatic hyperplasia who are unsatisfied with treatment with 0.2 mg tamsulosin [J] . Pei-Shan Yang, Chien-Lun Chen, Chen-Pang Hou, Clinical Interventions in Aging . 2018,第2期

机译：一项开放性，前瞻性的干预性研究，研究了0.4 mg口服坦索罗辛口服控制吸收系统对不满意0.2 mg坦索罗辛治疗的下尿路症状与良性前列腺增生有关的男性的耐受性和疗效
3. Re: Finasteride, Not Tamsulosin, Increases Severity of Erectile Dysfunction and Decreases Testosterone Levels in Men with Benign Prostatic Hyperplasia [J] . Kaplan Steven A. The Journal of Urology . 2017,第1期

机译：Re：小甾胺，而不是Tamsulosin，增加了勃起功能障碍的严重程度，并降低了良性前列腺增生的男性中的睾酮水平
4. Temperature Distribution of Microwave Balloon Treatment Benign Prostatic Hyperplasia using Finite Element Model [C] . Sinchai Jandang, Supan Tungjitkusolmun, Pattarapong Phasukkit Biomedical Engineering International Conference . 2019

机译：基于有限元模型的微波气球治疗前列腺增生症的温度分布
5. The Feasibility of Fourier Transform Infrared Imaging Spectroscopy in Discriminating Benign Prostatic Hyperplasia From Prostate Cancer in Blood Serum Samples [D] . Monjardez, Geraldine. 2013

机译：傅里叶变换红外成像光谱技术从血清样品中区分前列腺癌与前列腺癌的可行性
6. Sildenafil citrate in combination with tamsulosin versus tamsulosin monotherapy for management of male lower urinary tract symptoms due to benign prostatic hyperplasia: A randomised double-blind placebo-controlled trial [O] . Amr Fawzi, Mostafa Kamel, Emad Salem, 2017

机译：枸酸西地那非联合坦索罗辛与坦索罗辛单药联合治疗良性前列腺增生引起的男性下尿路症状：一项随机双盲安慰剂对照试验
7. A comparative study of fixed dose of Tamsulosin with finasteride vs Tamsulosin with dutasteride in the management of benign prostatic hyperplasia [O] . N K Mohanty, Uday Pratap Singh, Nitin K Sharma, 2006

机译：坦索罗辛固定剂量与非那雄胺联合坦索罗辛与度他雄胺治疗良性前列腺增生的对照研究

Additive effect of oral LDD175 to tamsulosin and finasteride in a benign prostate hyperplasia rat model

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