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Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway

机译：依普黄酮通过激活GPR30 / PI3K / AKT信号通路促进牙周膜细胞增殖和成骨分化

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摘要

ObjectivesThis study was performed to investigate the effects and mechanism of ipriflavone (IP) on the proliferation and osteoblastic differentiation of periodontal ligament cells in vitro and periodontal tissue remodeling following orthodontic tooth movement (OTM) in vivo.

机译：目的进行这项研究，以研究依普拉酮（IP）对体外正畸牙齿移动（OTM）后牙周膜细胞增殖和成骨细胞分化以及牙周组织重塑的影响和机制。

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期刊名称 Drug Design Development and Therapy
作者
Yuanyuan Han; Xuxia Wang; Dan Ma; Xiaoxiao Wu; Panpan Yang; Jun Zhang;
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作者单位

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年(卷),期 2018(12),-1
年度 2018
页码 137–148
总页数 12
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
ipriflavone periodontal ligament cells osteogenic differentiation GPR30 PI3K/AKT;

机译：依普拉酮;牙周膜细胞;成骨分化;GPR30;PI3K / AKT;

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专利

1. Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway [J] . Yuanyuan Han, Xuxia Wang, Dan Ma, Drug Design, Development and Therapy . 2018,第4期

机译：依普黄酮通过激活GPR30 / PI3K / AKT信号通路促进牙周膜细胞增殖和成骨分化
2. Rutin promotes osteogenic differentiation of periodontal ligament stem cells through the GPR30-mediated PI3K/AKT/mTOR signaling pathway [J] . Zhao Bin, Xiong Yixuan, Zhang Yunpeng, Experimental Biology and Medicine: Journal of the Society for Experimental Biology and Medicine . 2020,第6期

机译：Rutin通过GPR30介导的PI3K / AKT / MTOR信号通路促进牙周韧带干细胞的骨膜分化
3. Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway [J] . Yixuan Xiong, Bin Zhao, Wenjing Zhang, Iranian Journal of Basic Medical Sciences . 2020,第7期

机译：姜黄素通过PI3K / AKT / NRF2信号传导途径促进牙周韧带干细胞的成骨分化
4. PROLIFERATION AND OSTEOGENIC DIFFERENTIATION OF HUMAN PERIODONTAL LIGAMENT CELLS ON AKERMANITE AND p-TCP BIOCERAMICS [C] . Lunguo Xia, Zhiyuan Zhang, Lei Chen, Academic Committee conference of Shanghai key lab of stomatology . 2011

机译：钙长石和p-TCP生物陶瓷上人牙周膜细胞的增殖和成骨分化
5. The multi-targeted receptor tyrosine kinase inhibitor, linifanib (ABT-869), induces apoptosis and inhibits proliferation of leukemia cells through phosphoinositide-3 kinase (PI3K)/AKT-dependent signaling pathways. [D] . Hernandez, Jenny Elizabeth. 2010

机译：多靶点受体酪氨酸激酶抑制剂利尼法尼（ABT-869）通过磷酸肌醇3激酶（PI3K）/ AKT依赖性信号传导途径诱导凋亡并抑制白血病细胞的增殖。
6. Curcumin promotes osteogenic differentiation of periodontal ligament stem cells through the PI3K/AKT/Nrf2 signaling pathway [O] . Yixuan Xiong, Bin Zhao, Wenjing Zhang, 2020

机译：姜黄素通过PI3K / AKT / NRF2信号传导途径促进牙周韧带干细胞的成骨分化
7. Increased Osteogenic Differentiation of Periodontal Ligament Stem Cells on Polydopamine Film Occurs via Activation of Integrin and PI3K Signaling Pathways [O] . Jeong Seok Lee, Jin-Kyu Yi, Seong Yeong An, 2014

机译：通过整合素和pI3K信号通路的激活，增加牙周韧带干细胞在聚多巴胺膜上的成骨分化

Ipriflavone promotes proliferation and osteogenic differentiation of periodontal ligament cells by activating GPR30/PI3K/AKT signaling pathway

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