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High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

机译：加蓬儿童体内dhfr三突变体的高发生率及其与磺胺多辛-乙胺嘧啶体内治疗失败的高发生率相关

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摘要

BackgroundDrug resistance contributes to the global malaria burden. Plasmodium falciparum dihydrofolate reductase (dhfr) and dihydropteroate synthase (dhps) polymorphisms confer resistance to sulphadoxine-pyrimethamine (SP).

机译：背景耐药性加剧了全球疟疾负担。恶性疟原虫二氢叶酸还原酶（dhfr）和二氢蝶呤合酶（dhps）多态性赋予对磺胺多辛-乙胺嘧啶（SP）的抗性。

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期刊名称 Malaria Journal
作者
Ghyslain Mombo-Ngoma; Sunny Oyakhirome; Rosalynn Ord; Julian J Gabor; Katja C Greutélaers; Katharina Profanter; Benedikt Greutélaers; Florian Kurth; Bertrand Lell; Jürgen FJ Kun; Saadou Issifou; Cally Roper; Peter G Kremsner; Martin P Grobusch;
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年(卷),期 2011(10),-1
年度 2011
页码 123
总页数 8
原文格式 PDF
正文语种
中图分类寄生动物、寄生虫学;医学寄生虫学;
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1. High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children [J] . Ghyslain Mombo-Ngoma, Sunny Oyakhirome, Rosalynn Ord0, Malaria Journal . 2011,第S2期

机译：加蓬儿童体内dhfr三突变体的高患病率与体内磺胺多辛-乙胺嘧啶治疗失败的发生率高相关
2. Plasmodium falciparum dhfr but not dhps mutations associated with sulphadoxine-pyrimethamine treatment failure and gametocyte carriage in northern Ghana. [J] . Mockenhaupt FP, Teun Bousema J, Eggelte TA, Tropical Medicine and International Health: TM and IH . 2005,第9期

机译：在加纳北部，恶性疟原虫dhfr与dhps突变无关，而dhps突变与磺胺多辛-乙胺嘧啶治疗失败和配子细胞运输有关。
3. Increased prevalence of dhfr and dhps mutants at delivery in Malawian pregnant women receiving intermittent preventive treatment for malaria [J] . LinJ.T., MbeweB., TaylorS.M., Tropical Medicine and International Health: TM and IH . 2013,第2期

机译：接受间歇性疟疾预防治疗的马拉维孕妇分娩时dhfr和dhps突变体的患病率增加
4. Prevalence of Intestinal Parasites in Children in the Western Amazon and its correlation with the Pharmaceutical Assistance in Primary Health Care [C] . Melo W.A.L., Quaresma J.A.S., Muniz P.T. World Congress on Public Health . 2013

机译：西亚南部儿童肠寄生虫的患病率及其与初级保健药物援助的相关性
5. Prevalence of Mutant Dihydrofolate Reductase Gene (DHFR) and Its Implication on Pyrimethamine Resistance in Rural Kwara State, Nigeria [D] . Adebobola, Obaniyi Kehinde. 2021

机译：突变二氢脱液还原酶基因（DHFR）的患病率及其对尼日利亚农村克瓦拉州嘧嘧啶抗性的影响
6. Rapid increase of Plasmodium falciparum dhfr/dhps resistant haplotypes after the adoption of sulphadoxine-pyrimethamine as first line treatment in 2002 in southern Mozambique [O] . Sonia Enosse, Pascal Magnussen, Fatima Abacassamo, 2008

机译：2002年在莫桑比克南部采用磺胺多辛-乙胺嘧啶作为一线治疗后恶性疟原虫dhfr / dhps耐药单倍型迅速增加
7. High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children [O] . Ghyslain Mombo-Ngoma, Sunny Oyakhirome, Rosalynn Ord, 2011

机译：加蓬儿童体内dhfr三突变体的高发生率及其与磺胺多辛-乙胺嘧啶体内治疗失败的高发生率相关

High prevalence of dhfr triple mutant and correlation with high rates of sulphadoxine-pyrimethamine treatment failures in vivo in Gabonese children

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