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Pharmacokinetic comparison of sustained- and immediate-release formulations of cilostazol after multiple oral doses in fed healthy male Korean volunteers

机译：西洛他唑缓释和速释制剂多次口服后在健康的韩国男性志愿者中的药代动力学比较

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摘要

BackgroundA new extended-release form of cilostazol has recently been developed. This study was conducted to compare the pharmacokinetic characteristics of sustained-release (SR) and immediate-release (IR) formulations of cilostazol after multiple oral doses in healthy male Korean volunteers.

机译：背景技术最近已经开发了西洛他唑的新的缓释形式。这项研究的目的是比较健康男性韩国志愿者多次口服给药后西洛他唑的缓释（SR）和速释（IR）制剂的药代动力学特征。

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期刊名称 Drug Design Development and Therapy
作者
Yo Han Kim; Jong-Lyul Ghim; Jin Ah Jung; Sang-Heon Cho; Sangmin Choe; Hee Youn Choi; Kyun-Seop Bae; Hyeong-Seok Lim;
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作者单位

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年(卷),期 2015(9),-1
年度 2015
页码 3571–3577
总页数 7
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
cilostazol bioavailability sustained release immediate release pharmacokinetics healthy subjects;

机译：西洛他唑;生物利用度;持续释放;立即释放;药代动力学;健康受试者;

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1. Pharmacokinetic comparison of sustained- and?immediate-release formulations of cilostazol after multiple oral doses in fed healthy male Korean volunteers [J] . Yo Han Kim, Jong-Lyul Ghim, Jin Ah Jung, Drug Design, Development and Therapy . 2015,第4期

机译：西洛他唑缓释和速释制剂多次口服后在健康的韩国男性志愿者中的药代动力学比较
2. Pharmacokinetic comparison of sustained- and immediate-release oral formulations of cilostazol in healthy korean subjects: a randomized, open-label, 3-part, sequential, 2-period, crossover, single-dose, food-effect, and multiple-dose study. [J] . Lee D, Lim LA, Jang SB, Clinical therapeutics . 2011,第12期

机译：西洛他唑缓释和速释口服制剂在健康韩国受试者中的药代动力学比较：一项随机，开放标签，三部分，顺序，两期，交叉，单剂量，食物效应和多剂量研究。
3. Pharmacokinetic comparison of controlled- and immediate-release formulations of dexibuprofen after single and multiple oral doses in fasting healthy male Korean volunteers. [J] . Noh YH, Lim HS, Cho SH, Clinical therapeutics . 2011,第9期

机译：单次和多次口服后在空腹健康韩国男性志愿者中右旋布洛芬控释和速释制剂的药代动力学比较。
4. A Phase I, Double-Blind, Randomized, Dose Escalating Crossover Study ofan Oral Formulation of Human Growth Hormone in Healthy Male Volunteers [C] . Steven M. Dinh, Puchun Liu, Ehud Arbit, Controlled Release Society annual meeting . 2004

机译：健康男性志愿者中人类生长激素口服制剂的I期，双盲，随机，剂量递增交叉研究
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机译：硝苯地平新型喷雾包衣的软弹性明胶胶囊缓释制剂的开发，维拉帕米盐酸盐控释制剂的生物利用度和生物等效性，在猛禽中单次口服剂量后特比萘芬的药代动力学。
6. Safety tolerability and pharmacokinetics of the selective prostacyclin receptor agonist ralinepag in single and multiple dosing studies of an immediate-release oral formulation in healthy volunteers [O] . John S. Grundy, Christopher D. King, John W. Adams, 2020

机译：选择性前列环素受体激动剂ralinepag的安全性耐受性和药代动力学在健康志愿者中立即释放口腔制剂的单一和多重计量研究
7. Pharmacokinetic Comparison of 2 Fixed-Dose Combination Tablets of Amlodipine and Valsartan in Healthy Male Korean Volunteers: A Randomized, Open-Label, 2-Period, Single-Dose, Crossover Study [O] . Kim Yukyung, Son Mijeong, Lee Donghwan, 2013

机译：2种氨氯地平和缬沙坦固定剂量组合片剂在健康的男性韩国志愿者中的药代动力学比较：一项随机，开放标签，2期，单剂量，交叉研究

Pharmacokinetic comparison of sustained- and immediate-release formulations of cilostazol after multiple oral doses in fed healthy male Korean volunteers

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