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Phase II study of reintroduction of oxaliplatin for advanced colorectal cancer in patients previously treated with oxaliplatin and irinotecan: RE-OPEN study

机译：在先前接受过奥沙利铂和伊立替康治疗的患者中重新引入奥沙利铂治疗晚期大肠癌的II期研究：RE-OPEN研究

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摘要

BackgroundThe effectiveness of reintroducing oxaliplatin in patients with metastatic colorectal cancer refractory to standard chemotherapy has not been verified. We performed a single-arm, open-label, Phase II study to evaluate the safety and efficacy of reintroducing oxaliplatin.

机译：背景尚未证实在标准化疗难以治疗的转移性结直肠癌患者中重新引入奥沙利铂的有效性。我们进行了单臂，开放标签的II期研究，以评估重新引入奥沙利铂的安全性和有效性。

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期刊名称 Drug Design Development and Therapy
作者
Mitsukuni Suenaga; Nobuyuki Mizunuma; Satoshi Matsusaka; Eiji Shinozaki; Masato Ozaka; Mariko Ogura; Toshiharu Yamaguchi;
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作者单位

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年(卷),期 2015(9),-1
年度 2015
页码 3099–3108
总页数 10
原文格式 PDF
正文语种
中图分类药学;药物化学;
关键词
reintroduction oxaliplatin FOLFOX advanced colorectal cancer salvage-line;

机译：再引入;奥沙利铂;FOLFOX;晚期大肠癌;抢救路线;

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专利

1. CMAB009联合伊立替康或伊立替康单药二线治疗氟嘧啶和奥沙利铂治疗失败的KRAS野生型转移性结直肠癌患者的研究:一项前瞻性、开放、随机、Ⅲ期试验 [J] . 石远凯, 白丽, 张沂平, 癌症（英文版） . 2020,第007期
2. Phase II study of reintroduction of oxaliplatin for?advanced colorectal cancer in patients previously?treated with oxaliplatin and irinotecan: RE-OPEN study [J] . Mitsukuni Suenaga, Nobuyuki Mizunuma, Satoshi Matsusaka, Drug Design, Development and Therapy . 2015,第4期

机译：重新引入奥沙利铂治疗晚期大肠癌患者的II期研究：RE-OPEN研究
3. Modified CAPOX (capecitabine plus oxaliplatin) regimen every two weeks as second-line treatment in patients with advanced colorectal cancer previously treated with irinotecan-based frontline therapy: a multicenter phase II study. [J] . Kakolyris S, Souglakos J, Polyzos A, Oncology: International Journal of Cancer Research and Treatment . 2008,第1a2期

机译：每两周修改的CAPOX（卡培他滨加奥沙利铂）方案作为二线治疗，用于先前已接受基于伊立替康的一线治疗的晚期大肠癌患者：一项多中心II期研究。
4. Biweekly S-1 plus oxaliplatin (SOX) reintroduction in previously treated metastatic colorectal cancer patients (ORION 2 study): a phase II study to evaluate the efficacy and safety [J] . Tanioka Hiroaki, Honda Michitaka, Tanaka Chihiro, International journal of clinical oncology . 2019,第7期

机译：双周S-1加上oxaliplatin（Sox）重新引入先前治疗的转移性结肠直肠癌患者（ORION 2研究）：II期研究，以评估疗效和安全性
5. INTERACTIONS OF OXALIPLATIN AND CARBOPLATIN WITH DNA BUILDING BLOCKS AS STUDIED IN THE GAS PHASE: A COMBINED EXPERIMENTAL AND THEORETICAL STUDY [C] . Jean-Yves Salpin, Maria Elisa Crestoni, Davide Corinti, International Mass Spectrometry Conference . 2018

机译：在气相中研究的DNA构建块与DNA构建块的相互作用：一种实验与理论研究
6. Use and outcomes of newer chemotherapeutic agents in colorectal cancer patients using Irinotecan as a case study. [D] . Obeidat, Nour A. 2008

机译：以伊立替康为例的结直肠癌患者中新型化疗药物的使用和结果。
7. A phase II study of irinotecan plus chronomodulated oxaliplatin 5-fluorouracil and folinic acid in advanced colorectal cancer patients [O] . C Garufi, E Bria, B Vanni, 2003

机译：伊立替康联合调速的奥沙利铂5-氟尿嘧啶和亚叶酸对晚期大肠癌患者的II期研究
8. A phase II study of irinotecan plus chronomodulated oxaliplatin, 5-fluorouracil and folinic acid in advanced colorectal cancer patients [O] . Garufi, C, Bria, E, Vanni, B, 2003

机译：伊立替康联合调速的奥沙利铂，5-氟尿嘧啶和亚叶酸对晚期大肠癌患者的II期研究

Phase II study of reintroduction of oxaliplatin for advanced colorectal cancer in patients previously treated with oxaliplatin and irinotecan: RE-OPEN study

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