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Biodegradable stents for the treatment of bowel strictures in Crohns disease: technical results and challenges

机译:用于克罗恩病肠狭窄的可生物降解支架:技术成果和挑战

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摘要

>Background and study aims: In patients with Crohn’s disease, the idea of biodegradable stents for treatment of bowel strictures with limited effect of endoscopic balloon dilation is tempting and initial results have been promising. The aim of this study was to evaluate the technical and clinical success of biodegradable stents for treatment of inflamed Crohn’s strictures refractory to endoscopic balloon dilatation. >Patients and methods: Consecutive patients treated with biodegradable stents due to Crohn’s disease and inflamed bowel strictures refractory to endoscopic balloon dilatation were included. Technical and clinical success were evaluated. >Results: Six patients were included in the study. Technical success was obtained in five patients (83 %). Clinical success was limited to one patient (20 %); failure was observed due to mucosal overgrowth (n = 2), stent migration (n = 1), and stent collapse (n = 1). >Conclusions: In Crohn’s disease, it is technically feasible to treat bowel strictures with biodegradable stents. However, we have stopped using biodegradable stents due to lack of clinical success and side effects such as mucosal overgrowth and stent collapse.
机译:>背景和研究目标:在克罗恩病患者中,可生物降解的支架用于治疗肠狭窄的内镜球囊扩张作用有限的想法很诱人,并且初步结果令人鼓舞。这项研究的目的是评估可生物降解支架在治疗内镜下球囊扩张难治的发炎性克罗恩狭窄中的技术和临床成功性。 >患者和方法:包括因克罗恩病和因内镜下球囊扩张难治的肠狭窄发炎而使用可生物降解支架治疗的连续患者。评价技术和临床成功率。 >结果:该研究包括6名患者。五名患者(83%)获得技术成功。临床成功仅限于一名患者(20%);观察到由于粘膜过度生长(n = 2),支架迁移(n = 1)和支架塌陷(n = 1)引起的衰竭。 >结论:在克罗恩氏病中,使用可生物降解的支架治疗肠狭窄在技术上是可行的。但是,由于缺乏临床上的成功和诸如粘膜过度生长和支架塌陷等副作用,我们已停止使用可生物降解的支架。

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