Background: In contrast with established evidence linking high doses of ionizing radiation with childhood cancer, research on low-dose ionizing radiation and childhood cancer has produced inconsistent results.Objective: We investigated the association between domestic radon exposure and childhood cancers, particularly leukemia and central nervous system (CNS) tumors.Methods: We conducted a nationwide census-based cohort study including all children < 16 years of age living in Switzerland on 5 December 2000, the date of the 2000 census. Follow-up lasted until the date of diagnosis, death, emigration, a child’s 16th birthday, or 31 December 2008. Domestic radon levels were estimated for each individual home address using a model developed and validated based on approximately 45,000 measurements taken throughout Switzerland. Data were analyzed with Cox proportional hazard models adjusted for child age, child sex, birth order, parents’ socioeconomic status, environmental gamma radiation, and period effects.Results: In total, 997 childhood cancer cases were included in the study. Compared with children exposed to a radon concentration below the median (< 77.7 Bq/m3), adjusted hazard ratios for children with exposure ≥ the 90th percentile (≥ 139.9 Bq/m3) were 0.93 (95% CI: 0.74, 1.16) for all cancers, 0.95 (95% CI: 0.63, 1.43) for all leukemias, 0.90 (95% CI: 0.56, 1.43) for acute lymphoblastic leukemia, and 1.05 (95% CI: 0.68, 1.61) for CNS tumors.Conclusions: We did not find evidence that domestic radon exposure is associated with childhood cancer, despite relatively high radon levels in Switzerland.Citation: Hauri D, Spycher B, Huss A, Zimmermann F, Grotzer M, von der Weid N, Weber D, Spoerri A, Kuehni C, Röösli M, for the Swiss National Cohort and the Swiss Paediatric Oncology Group (SPOG). 2013. Domestic radon exposure and risk of childhood cancer: a prospective census-based cohort study. Environ Health Perspect 121:1239–1244;
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机译：背景：与将高剂量电离辐射与儿童期癌症联系起来的现有证据相反，低剂量电离辐射与儿童期癌症的研究产生了不一致的结果。目的：我们调查了家中ra暴露与儿童期癌症（特别是白血病和中枢性癌症）之间的关系。方法：我们于2000年12月5日（即2000年人口普查之日）在瑞士进行了一项全国性的以人口普查为基础的队列研究，其中包括所有16岁以下的儿童。随访一直持续到诊断，死亡，移民，儿童16岁生日或2008年12月31日为止。根据在整个瑞士进行的大约45,000次测量得出的模型，开发并验证了每个家庭住所的Domestic含量。使用针对儿童年龄，儿童性别，出生顺序，父母的社会经济状况，环境伽玛射线和周期影响而调整的Cox比例风险模型分析数据。结果：总共纳入了997例儿童癌症病例。与暴露于below浓度低于中位数（<77.7 Bq / m 3 ）的儿童相比，暴露≥90％的儿童（≥139.9 Bq / m 3 ）对于所有癌症而言均为0.93（95％CI：0.74，1.16），对于所有白血病而言分别为0.95（95％CI：0.63、1.43），对于急性淋巴细胞白血病为0.90（95％CI：0.56、1.43）和1.05（ 95％CI：0.68，1.61）结论：尽管瑞士的ra水平相对较高，但我们没有发现证据表明家庭中的exposure暴露与儿童期癌症有关。引用：Hauri D，Spycher B，Huss A，Zimmermann F ，Grotzer M，von der Weid N，Weber D，Spoerri A，Kuehni C，RöösliM，代表瑞士国家队列研究和瑞士儿科肿瘤小组（SPOG）。 2013。家庭ra暴露与儿童癌症风险：一项基于人口普查的前瞻性队列研究。环境健康透视121：1239–1244；
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