DDT Exposure of Zebrafish Embryos Enhances Seizure Susceptibility: Relationship to Fetal pp′-DDE Burden and Domoic Acid Exposure of California Sea Lions

摘要

Background California sea lions have a large body burden of organochlorine pesticides, and over the last decade they have also been subject to domoic acid poisoning. Domoic acid poisoning, previously recognized in adult animals, is now viewed as a major cause of prenatal mortality. The appearance of a chronic juvenile domoic acid disease in the sea lions, characterized by behavioral abnormalities and epilepsy, is consistent with early life poisoning and may be potentiated by organochlorine burden.