Nucleosome positioning and transcription: fission yeast CHD remodellers make their move

摘要

EMBO J (2012) 31 23, 4388–4403 doi:10.1038/emboj.2012.289; published online October262012 [] [] []EMBO J (2012) 31 23, 4375–4387 doi:10.1038/emboj.2012.267; published online September182012 [] [] []EMBO Reports (2012) 31 11, 997–1003 doi:10.1038/embor.2012.146; published online October22012 class="nowrap">[]Regularly positioned nucleosomes are a common feature of 5′ ends of most eukaryotic genes. A series of three studies, Shim et al (2012) and Pointner et al (2012) in this issue of The EMBO Journal and Hennig et al (2012) in EMBO Reports, now show that in the fission yeast Schizosaccharomyces pombe this intragenic nucleosome positioning mostly requires two ATP-dependent remodellers of the CHD family, Hrp1 and Hrp3. Moreover, they suggest that Hrp1- and Hrp3-dependent nucleosome spacing contributes to the silencing of cryptic antisense transcription.