转录起始位点核小体定位的研究进展

摘要

核小体定位是参与真核生物基因表达调控的一种重要的表观遗传因素，深刻影响基因转录、DNA复制与修复等生物学过程。对于在许多基因位点，比如转录起始位点（TSS)、转录因子结合位点（TFBS)等处的核小体定位已有不少报道。主要介绍了核小体的定位特性，综述了转录起始位点处核小体的定位特征，分别从序列依赖性因素和DNA甲基化、组蛋白变体及修饰、染色质重塑、可变剪接等表观遗传因素较为详细地概括了转录起始位点核小体定位的研究进展。%Nucleosome mapping,an important epigenetic factor participating in regulating eukaryotic gene expression, deeply affects lots of biological processes,including gene transcription,DNA replication,DNA repair and so forth. The nucleosome mapping around TSS and TFBS has been reported properties of nucleosome mapping were introduced in this paper. Features in nucleosome mapping around TSS were summarized. Advances on nucleosome mapping around TSS from both the DNA sequence-dependent factor and some epigenetic factors including DNA methylation, variants and modification of histone, chromation remodeling,alternative splicing were reviewed.