Cardiac Systolic Mechanics in Heart Failure with Preserved Ejection Fraction: New Insights and Controversies

摘要

Heart failure with preserved ejection fraction (HFpEF) is a cardinal and complex syndrome tightly linked to several co-morbidities, and is currently emerging as a new public health problem in the elderly population. However, despite aggressive intervention, patients with HFpEF typically have a poor prognosis. Part of the reason underlying this phenomenon can be attributed to the insufficiently understood pathophysiology behind this syndrome. Traditional echocardiography-derived parameters such as left ventricular (LV) ejection fraction (LVEF) may not be useful in characterizing such a clinical disorder, or in further identifying the subjects at risk, owing in part to its lack of power to disclose subclinical systolic dysfunction in such a clinical scenario. Herein, we briefly reviewed the clinical manifestations and risk factors of HFpEF, and further provided insights into the understanding of the ventricular architecture and cardiac mechanics underlying HFpEF by utilizing advanced cardiovascular imaging modalities, with a special focus on myocardial deformation.