Urine Metabolomics by 1H-NMR Spectroscopy Indicates Associations between Serum 35-T2 Concentrations and Intermediary Metabolism in Euthyroid Humans

摘要

Context3,5-Diiodo-L-thyronine (3,5-T2) is a thyroid hormone metabolite which exhibited versatile effects in rodent models, including the prevention of insulin resistance or hepatic steatosis typically forced by a high-fat diet. With respect to euthyroid humans, we recently observed a putative link between serum 3,5-T2 and glucose but not lipid metabolism.