The antiobesity effects of a P. aviculare ethanol extract (PAE) in high-fat diet- (HFD-) induced obese mice were investigated. The mice were fed an HFD or an HFD supplemented with PAE (400 mg/kg/day) for 6.5 weeks. The increased body weights, adipose tissue weight, and adipocyte area as well as serum total triglyceride, leptin, and malondialdehyde concentrations were decreased in PAE-treated HFD-induced obese mice relative to the same measurements in untreated obese mice. Furthermore, PAE significantly suppressed the elevated mRNA expression levels of sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor γ, fatty acid synthase, and adipocyte protein 2 in the white adipose tissue of obese mice. In addition, PAE treatment of 3T3-L1 cells inhibited adipocyte differentiation and fat accumulation in a dose-dependent manner. These results suggest that PAE exerts antiobesity effects in HFD-induced obese mice through the suppression of lipogenesis in adipose tissue and increased antioxidant activity.
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机译：研究了高脂肪饮食（HFD-）诱导的肥胖小鼠肺泡败血性乙醇提取物（PAE）的抗肥胖作用。给小鼠喂食HFD或补充有PAE（400μmg/ kg /天）的HFD 6.5周。与未治疗的肥胖小鼠中的相同测量值相比，PAE治疗的HFD诱导的肥胖小鼠中增加的体重，脂肪组织重量和脂肪细胞面积以及血清总甘油三酯，瘦素和丙二醛浓度降低。此外，PAE显着抑制了肥胖小鼠白色脂肪组织中固醇调节元件结合蛋白1c，过氧化物酶体增殖物激活的受体γ，脂肪酸合酶和脂肪细胞蛋白2的mRNA表达水平升高。此外，PAE处理3T3-L1细胞以剂量依赖的方式抑制了脂肪细胞的分化和脂肪的积累。这些结果表明，PAE通过抑制脂肪组织中的脂肪生成和增加的抗氧化活性，在HFD诱导的肥胖小鼠中发挥抗肥胖作用。
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