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The CNP signal is able to silence a supra threshold neuronal model

机译:CNP信号能够使超阈值神经元模型沉默

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摘要

Several experimental results published in the literature showed that weak pulsed magnetic fields affected the response of the central nervous system. However, the specific biological mechanisms that regulate the observed behaviors are still unclear and further scientific investigation is required. In this work we performed simulations on a neuronal network model exposed to a specific pulsed magnetic field signal that seems to be very effective in modulating the brain activity: the Complex Neuroelectromagnetic Pulse (CNP). Results show that CNP can silence the neurons of a feed-forward network for signal intensities that depend on the strength of the bias current, the endogenous noise level and the specific waveforms of the pulses. Therefore, it is conceivable that a neuronal network model responds to the CNP signal with an inhibition of its activity. Further studies on more realistic neuronal networks are needed to clarify if such an inhibitory effect on neuronal tissue may be the basis of the induced analgesia seen in humans and the antinociceptive effects seen in animals when exposed to the CNP.
机译:文献中发表的一些实验结果表明,弱脉冲磁场会影响中枢神经系统的反应。然而,尚不清楚调节观察到的行为的具体生物学机制,需要进一步的科学调查。在这项工作中,我们对暴露于特定脉冲磁场信号的神经网络模型进行了仿真,该信号似乎对调节大脑活动非常有效:复杂神经电磁脉冲(CNP)。结果表明,CNP可以使前馈网络的神经元沉默,使其信号强度取决于偏置电流的强度,内生噪声水平和特定的脉冲波形。因此,可以想象的是,神经元网络模型通过抑制其活性来响应CNP信号。需要进一步研究更现实的神经元网络,以阐明这种对神经元组织的抑制作用是否可能是人体暴露于CNP后所见的诱导性镇痛和动物所见的镇痛作用的基础。

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